久久综合九色综合欧洲色-久久综合九色综合桃花-久久综合九色综合网站-久久综合久久综合九色-亚洲影院在线播放-亚洲永久视频

技術文章您現(xiàn)在的位置:首頁 > 技術文章 > ClickChemistryTools點擊化學銅配體THPTA

ClickChemistryTools點擊化學銅配體THPTA

更新時間:2022-12-24   點擊次數(shù):1684次

中文介紹:

THPTA(三羥丙基三唑基甲胺)是一種水溶性、非常有效的加速配體,用于銅催化的炔烴-疊氮化物點擊化學反應(CuAAC)。除了大大提高CuAAC的速率外,THPTA還最大限度地減少了對所探測細胞或生物體生理狀態(tài)的擾動,并通過進一步降低催化劑配方中的Cu負載量,允許有效的生物偶聯(lián)與抑制細胞細胞毒性。水溶性THPTA配體允許整個反應在水中運行,進一步簡化了點擊化學。


英文介紹:

THPTA (tris-hydroxypropyltriazolylmethylamine) is a water-soluble, very effective accelerating ligand for copper-catalyzed Alkyne-Azide click chemistry reactions (CuAAC). In addition to greatly enhancing the rate of CuAAC, THPTA minimizes perturbations to the physiological state of the cells or organisms probed and allows for the effective bioconjugation with suppressed cell cytotoxicity by further lowering Cu loading in the catalyst formulation. The water-soluble THPTA ligand further simplifies click chemistry by allowing the entire reaction to be run in water.


產(chǎn)品參數(shù):



參考文獻:

1. Graham, A. J., et al. (2022). Extracellular Electron Transfer Enables Cellular Control of Cu(I)-Catalyzed Alkyne-Azide Cycloaddition. ACS Cent Sci., 8 (2), 246-257.

2. Loebel , C., et al. (2022). Metabolic labeling of secreted matrix to investigate cell-material interactions in tissue engineering and mechanobiology. Nat Protoc., 10.1038, Online ahead of print.

3. Leach, R. W., et al. (2021). Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation. Nat Chem Biol., 17 (11), 1178-1187.

4. Buch-Larsen, S. C., et al. (2021). Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets. Elife, 10, e60480.

5. Kang, D., et al. (2021). Bioorthogonal Retro-Cope Elimination Reaction of N, N-Dialkylhydroxylamines and Strained Alkynes. J Am Chem Soc., 143 (15), 5616-5621.

6. Bazrafshan, A. et al. (2021). DNA Gold Nanoparticle Motors Demonstrate Processive Motion with Bursts of Speed Up to 50 nm Per Second. ACS Publications, Online ahead of print.

7. Baskin, J. A., et al. (2021). A chemoproteomics approach to profile phospholipase D-derived phosphatidyl alcohol interactions. Cambridge: Cambridge Open Engage, This content is a preprint and has not been peer-reviewed.

8. Batrouni, A. G., et al. (2021). A palmitoylation code controls PI4KIIIα complex formation and PI(4,5)P2 homeostasis at the plasma membrane bioRxiv, This content is a preprint and has not been peer-reviewed.

9. Feng, S., et al. (2021). Combining Metabolic Alkyne Labeling and Click Chemistry for Secretome Analysis of Serum-Containing Conditioned Medium?. Chin. J. Chem., 39, 1843-1848.

10. Willems, L. I., et al. (2020). Tandem Bioorthogonal Labeling Uncovers Endogenous Cotranslationally O-GlcNAc Modified Nascent Proteins. J Am Chem Soc., 142 (37), 15729-15739.

11. Daughtry, J. L., et al. (2020). Clickable Galactose Analogues for Imaging Glycans in Developing Zebrafish. ACS Chem Biol., 15 (2), 318-324.

12. Tong, M., et al. (2020). Effective Method for Accurate and Sensitive Quantitation of Rapid Changes of Newly Synthesized Proteins. Anal. Chem., 92(14), 10048-57.



靶點科技(北京)有限公司

靶點科技(北京)有限公司

地址:中關村生命科學園北清創(chuàng)意園2-4樓2層

© 2024 版權所有:靶點科技(北京)有限公司  備案號:京ICP備18027329號-2  總訪問量:264494  站點地圖  技術支持:化工儀器網(wǎng)  管理登陸

主站蜘蛛池模板: 青草视频在线| 日本视频播放免费线上观看| 欧美日韩在线视频| 欧美午夜在线视频| 色噜噜 男人的天堂在线观看| 三级黄色片日韩| 一级毛片真人不卡免费播| 亚洲精品国精品久久99热| 欧美国产伦久久久久| 青青青久热国产精品视频| 亚洲乱码卡一卡二卡三永久| 欧美精品v欧洲精品| 亚洲春色在线视频| 青青青青久久久久国产的| 日韩免费小视频| 午夜看片影院在线观看| 四虎国产精品永久在线播放 | 热国产热综合| 亚洲美女高清一区二区三区| 日本乱码视频a| 一级韩国aa毛片免费观看| 性吧影院| 四虎国产一区| 欧美护士丝袜办公室激情| 亚洲欧美精品久久| 一本久久综合| 亚洲日韩中文第一精品| 天堂网www在线资源中文| 日韩美女片视频| 亚洲不卡| 亚洲综合国产一区在线| 日韩视频第一页| 亚洲视频国产视频| 日本高清免费一本视频在线观看| 人人干操| 日韩丝袜亚洲国产欧美一区| 亚洲精品资源| 亚洲欧美一区二区三区图片| 欧美一级在线播放| 欧美精品黄页免费高清在线 | 欧美一级中文字幕|